Chop collard greens into bite-sized pieces (discard tough stems); cook bacon in a large pot until crispy, remove and chop, leaving 2 tablespoons drippings.
Sauté diced onion and minced garlic in bacon drippings for 2 minutes, add collards with 1/4 cup water, cover and cook 6 minutes until tender.
While greens cook, pat tilapia dry, coat both sides with blackening seasoning, and sear in a hot skillet 3 minutes per side until cooked through.
Stir cream and cooked bacon into the collards, simmer 2 minutes.
Plate tilapia with creamed collards on the side.