Start rice pilaf by cooking rice in chicken broth with 1 tbsp butter and salt according to package directions.
Pat tilapia dry, season both sides with cajun seasoning and garlic powder, then pan-fry in 2 tbsp butter over medium-high heat for 3 minutes per side until opaque.
Remove fish to a plate, reduce heat to low, and add lemon juice and cream to the pan with remaining 1 tbsp butter, stirring to combine for 1 minute.
Plate fish over rice, drizzle with lemon cream sauce, and serve with lemon wedges.